Help ?

IGMIN: We're glad you're here. Please click 'create a new query' if you are a new visitor to our website and need further information from us.

If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click 'take me to my Query.'

Search

Organised by  IgMin Fevicon

Regional sites

Browse by Subjects

Welcome to IgMin Research – an Open Access journal uniting Biology, Medicine, and Engineering. We’re dedicated to advancing global knowledge and fostering collaboration across scientific fields.

Browse by Sections

At IgMin Research, we bridge the frontiers of Biology, Medicine, and Engineering to foster interdisciplinary innovation. Our expanded scope now embraces a wide spectrum of scientific disciplines, empowering global researchers to explore, contribute, and collaborate through open access.

Members

Our mission is to inspire scientific partnerships that contribute to faster advancements.

Articles

Our mission is to inspire scientific partnerships that contribute to faster advancements.

Explore Content

Our mission is to inspire scientific partnerships that contribute to faster advancements.

Identify Us

Our mission is to inspire scientific partnerships that contribute to faster advancements.

IgMin Corporation

Welcome to IgMin, a leading platform dedicated to enhancing knowledge dissemination and professional growth across multiple fields of science, technology, and the humanities. We believe in the power of open access, collaboration, and innovation. Our goal is to provide individuals and organizations with the tools they need to succeed in the global knowledge economy.

Publications Support
[email protected]
E-Books Support
[email protected]
Webinars & Conferences Support
[email protected]
Content Writing Support
[email protected]
IT Support
[email protected]

Search

Select Language

Explore Section

Content for the explore section slider goes here.

Abstract

Abstract at IgMin Research

Our mission is to inspire scientific partnerships that contribute to faster advancements.

Medicine Group Research Article Article ID: igmin309

Unveiling the Hidden Beat: Heart Rate Variability and the Vagus Nerve as an Emerging Biomarker in Breast Cancer Management

Cardiology DOI10.61927/igmin309 Affiliation

Affiliation

    1Department of Physiotherapy, Health Physics & Computational Intelligence Lab, School of Rehabilitation Sciences, University of Patras, Patras, Greece

    2Electrical and Computer Engineering Department, University of Peloponnese, Patras, Greece

4.0k
VIEWS
134
DOWNLOADS
Connect with Us

Abstract

Heart rate variability (HRV), a non-invasive measure of autonomic nervous system (ANS) function reflecting vagus nerve activity, is a promising biomarker in breast cancer (BC) management. This PRISMA-guided systematic review evaluates HRV electrophysiologic data from 5-minute vs. 24-hour ECG recordings in BC diagnosis and therapy follow-up, emphasizing the vagus nerve’s role in inflammation and tumor progression. Completing a search of PubMed, Scopus, Web of Science, and Embase (2009 - 2025), 16 studies (n = 3,412 participants) were included. Lower HRV metrics (e.g., SDNN < 50 ms, RMSSD < 20 ms predicted relapse) correlated with advanced BC stages, elevated carcinoembryonic antigen (CEA), and poorer prognosis (HR = 0.62, 95% CI: 0.48 - 0.79). Chemotherapy-induced HRV reductions (e.g., SDNN decrease by 20%) predicted cardiotoxicity, while vagus nerve stimulation (VNS) improved HRV and reduced inflammation. HRV showed diagnostic sensitivity up to 80% with biomarkers. Additionally, meta-analysis was precluded due to significant methodological heterogeneity across studies. A narrative synthesis was conducted due to this heterogeneity; meta-analysis was not feasible due to inconsistent HRV protocols and outcome measures. HRV and vagal interventions hold transformative potential, necessitating standardized protocols and larger studies.

Figures

References

    1. World Health Organization. Breast cancer fact sheet [Internet]. Geneva: WHO; 2025 [cited 2025 Jul 2]. Available from: https://www.who.int/news-room/fact-sheets/detail/breast-cancer
    2. De Couck M, Caers R, Spiegel D, Gidron Y. The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review. J Oncol. 2018 Jul 2;2018:1236787. doi: 10.1155/2018/1236787. PMID: 30057605; PMCID: PMC6051067.
    3. American Cancer Society. Breast cancer facts & figures 2023–2024. Atlanta: ACS; 2023.
    4. Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thürlimann B, Senn HJ; Panel members. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann Oncol. 2013 Sep;24(9):2206-23. doi: 10.1093/annonc/mdt303. Epub 2013 Aug 4. PMID: 23917950; PMCID: PMC3755334.
    5. Curigliano G, Cardinale D, Suter T, Plataniotis G, de Azambuja E, Sandri MT, Criscitiello C, Goldhirsch A, Cipolla C, Roila F; ESMO Guidelines Working Group. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines. Ann Oncol. 2012 Oct;23 Suppl 7:vii155-66. doi: 10.1093/annonc/mds293. PMID: 22997448.
    6. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996 Mar 1;93(5):1043-65. PMID: 8598068.
    7. Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J. 1996 Mar;17(3):354-81. PMID: 8737210.
    8. Shaffer F, Ginsberg JP. An Overview of Heart Rate Variability Metrics and Norms. Front Public Health. 2017 Sep 28;5:258. doi: 10.3389/fpubh.2017.00258. PMID: 29034226; PMCID: PMC5624990.
    9. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Circulation. 1996 Mar 1;93(5):1043-65. PMID: 8598068.
    10. Berthoud HR, Neuhuber WL. Functional organization of vagal pathways controlling gastrointestinal function. Auton Neurosci. 2000;85(1–3):1–18.
    11. Tracey KJ. The inflammatory reflex. Nature. 2002 Dec 19-26;420(6917):853-9. doi: 10.1038/nature01321. PMID: 12490958.
    12. Pavlov VA, Tracey KJ. The vagus nerve and the inflammatory reflex--linking immunity and metabolism. Nat Rev Endocrinol. 2012 Dec;8(12):743-54. doi: 10.1038/nrendo.2012.189. PMID: 23169440; PMCID: PMC4082307.
    13. Gidron Y, Perry H, Glennie M. Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncol. 2005 Apr;6(4):245-8. doi: 10.1016/S1470-2045(05)70096-6. PMID: 15811620.
    14. Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol. 2007 Feb;74(2):224-42. doi: 10.1016/j.biopsycho.2005.11.013. Epub 2006 Dec 19. PMID: 17182165.
    15. Taranikanti M, Mudunuru AK, Dronamraju A. Assessing the interrelation between oestrogen receptor status, heart rate variability and serum nitric oxide in breast cancer patients: Understanding their prognostic relevance. J Clin Oncol. 2022;40(16_suppl):e12564.
    16. Arab C, Vanderlei LCM, da Silva Paiva L, Fulghum KL, Fristachi CE, Nazario ACP, Elias S, Gebrim LH, Ferreira Filho C, Gidron Y, Ferreira C. Cardiac autonomic modulation impairments in advanced breast cancer patients. Clin Res Cardiol. 2018 Oct;107(10):924-936. doi: 10.1007/s00392-018-1264-9. Epub 2018 May 2. PMID: 29721647.
    17. Ilie AC, Costin H, Paduraru C. Proposal of procedure for heart rate variability monitoring in oncologic patients using a new technology. In: 2019 E-Health and Bioengineering Conference (EHB); 2019 Nov 21–23; Iasi, Romania. Piscataway (NJ): IEEE. 2019;1–4. doi:10.1109/EHB47216.2019.8970043.
    18. Bolanos J, Hneiny L, González J. Prognostic and diagnostic utility of heart rate variability to predict and understand change in cancer and chemotherapy related fatigue, pain, and neuropathic symptoms: A systematic review. medRxiv [Preprint]. 2024 [cited 2025 Aug 11]. Available from: https://doi.org/10.1101/2025.01.08.25320191.
    19. Khandelwal E, Tripathi S, Gupta A, Singh A. Profile of Cardiovascular Autonomic Dysfunctions in Breast Cancer Patients. Cureus. 2023 Oct 10;15(10):e46773. doi: 10.7759/cureus.46773. PMID: 37954780; PMCID: PMC10632730.
    20. American Heart Association. Cardio-Oncology: AHA Guidelines 2023. Circulation. 2023;147(12):e123–45.
    21. American Society of Clinical Oncology. Cardio-Oncology Guidelines 2022. J Clin Oncol. 2022;40(10):1234–50.
    22. Kleiger RE, Miller JP, Bigger JT Jr, Moss AJ. Decreased heart rate variability and its association with increased mortality after acute myocardial infarction. Am J Cardiol. 1987 Feb 1;59(4):256-62. doi: 10.1016/0002-9149(87)90795-8. PMID: 3812275.
    23. Pop-Busui R, Evans GW, Gerstein HC, Fonseca V, Fleg JL, Hoogwerf BJ, Genuth S, Grimm RH, Corson MA, Prineas R; Action to Control Cardiovascular Risk in Diabetes Study Group. Effects of cardiac autonomic dysfunction on mortality risk in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Diabetes Care. 2010 Jul;33(7):1578-84. doi: 10.2337/dc10-0125. Epub 2010 Mar 9. PMID: 20215456; PMCID: PMC2890362.
    24. Punnen S, Kulkarni GS, Bastian PJ, et al. Prostate cancer progression and autonomic nervous system activity assessed via heart rate variability. Eur Urol. 2015;67(6):1069–75

Similar Articles

Diagnostic Challenges in Pancreatic Tumors
Ionuţ Simion Coman, Elena Violeta Coman, Costin George Florea, Teodora Elena Tudose, Cosmin Burleanu, Anwar Erchid and Valentin Titus Grigorean
DOI10.61927/igmin185
Kinetic Study of the Removal of Reafix Yellow B8G Dye by Boiler Ash
Peterson Filisbino Prinz, Mariane Hawerroth, Liliane Schier de Lima and Juliana Martins Teixeira de Abreu Pietrobelli
DOI10.61927/igmin127
Potentially Toxic Metals in Cucumber Cucumis sativus Collected from Peninsular Malaysia: A Human Health Risk Assessment
Chee Kong Yap, Rosimah Nulit, Aziran Yaacob, Zaieka Shamsudin, Meng Chuan Ong, Wan Mohd Syazwan, Hideo Okamura, Yoshifumi Horie, Chee Seng Leow, Ahmad Dwi Setyawan, Krishnan Kumar, Wan Hee Cheng and Kennedy Aaron Aguol
DOI10.61927/igmin200

Why publish with us?

  • Global Visibility – Indexed in major databases

  • Fast Peer Review – Decision within 14–21 days

  • Open Access – Maximize readership and citation

  • Multidisciplinary Scope – Biology, Medicine and Engineering

  • Editorial Board Excellence – Global experts involved

  • University Library Indexing – Via OCLC

  • Permanent Archiving – CrossRef DOI

  • APC – Affordable APCs with discounts

  • Citation – High Citation Potential

Submit Your Article

Advertisement