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Early Online

Early Online (Volume - 3 | Issue - 8) at IgMin Research

We strive to cultivate connections between disciplines to foster new insights and advancements.

Engineering Group (1)

Perspective Article ID: igmin308
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

Human Missions to Mars Using the Starship
by Donald Rapp

A human mission to Mars has been widely regarded as the ultimate goal for space exploration in our time. Exploration of Mars has been limited to observations from orbit and a few rover expeditions that each cover about 20 km. The vast amount of Mars surface remains to be explored in situ. These limitations were mainly due to the cost of launching high mass payloads to Mars. After 100 years and a thousand studies, human missions to Mars remain in an early concept stage. The advent of the SpaceX Starship with its putative capability to affordably... land a 100 MT payload on Mars enables new, more ambitious approaches for exploring Mars at a grander scale. Here, we outline a mission to scientifically explore a wide swath of Mars utilizing the SpaceX Starship to deliver unprecedented amounts of materiel to Mars. A main landing site provides the command-and-control hub for distributed assets across Mars. A pair of communication satellites enables almost instantaneous command, control, and data retrieval. While SpaceX viewed this mission as an early step in establishing a settlement on Mars, we view it as an opportunity to scientifically explore the planet. Two variations of the mission employ different approaches for returning from Mars. The Mars Leviathan mission utilizes a Starship to leave LEO, land on Mars, and return from Mars to LEO. The major challenge in the “Mars Leviathan” mission is to produce a large mass of propellants via ISRU to ascend the crew of 12 in a Starship from Mars and return to Earth. Alternatively, we propose a “DRA-6” mission that uses a Starship to leave LEO and land on Mars, but for return, it uses a small capsule to lift a crew of six from Mars and rendezvous with an Earth Return Vehicle waiting in Mars orbit. The added capability of Starship enables the avoidance of the challenges involved in utilizing indigenous water on Mars by bringing water from Earth. In addition, water for life support is brought from Earth.

Aerospace Engineering

Medicine Group (1)

Research Article Article ID: igmin309
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

Unveiling the Hidden Beat: Heart Rate Variability and the Vagus Nerve as an Emerging Biomarker in Breast Cancer Management
by Constantinos KoutsojannisAthanasios Fouras, Dionysia Chrysanthakopoulou, Ioanna Michou and Savvina Mariettou

Heart rate variability (HRV), a non-invasive measure of autonomic nervous system (ANS) function reflecting vagus nerve activity, is a promising biomarker in breast cancer (BC) management. This PRISMA-guided systematic review evaluates HRV electrophysiologic data from 5-minute vs. 24-hour ECG recordings in BC diagnosis and therapy follow-up, emphasizing the vagus nerve’s role in inflammation and tumor progression. Completing a search of PubMed, Scopus, Web of Science, and Embase (2009 - 2025), 16 studies (n = 3,412 participants) were inclu...ded. Lower HRV metrics (e.g., SDNN < 50 ms, RMSSD < 20 ms predicted relapse) correlated with advanced BC stages, elevated carcinoembryonic antigen (CEA), and poorer prognosis (HR = 0.62, 95% CI: 0.48 - 0.79). Chemotherapy-induced HRV reductions (e.g., SDNN decrease by 20%) predicted cardiotoxicity, while vagus nerve stimulation (VNS) improved HRV and reduced inflammation. HRV showed diagnostic sensitivity up to 80% with biomarkers. Additionally, meta-analysis was precluded due to significant methodological heterogeneity across studies. A narrative synthesis was conducted due to this heterogeneity; meta-analysis was not feasible due to inconsistent HRV protocols and outcome measures. HRV and vagal interventions hold transformative potential, necessitating standardized protocols and larger studies.

Cardiology

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