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Abstract

Abstract at IgMin Research

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Wishful Thinking about Consciousness

Affiliation

Affiliation

    Mathematical Institute, University of Oxford, England

Abstract

We contrast three very distinct mathematical approaches to the hard problem of consciousness: quantum consciousness, integrated information theory, and the very large-scale dynamical systems simulation of a network of networks. We highlight their features and their associated hypotheses, and we discuss how they are aligned or in conflict. We suggest some challenges to these theories, in considering how they might apply to the human brain as it develops both cognitive and conscious sophistication, from infancy to adulthood. We indicate how an evolutionary perspective challenges the distinct approaches to aver performance advantages and physiological surrogates for consciousness.

References

    1. Chalmers DJ. Facing up to the Problem of Consciousness, Journal of Consciousness Studies. 1995; 2: 200-19.
    2. Chalmers DJ. The Conscious Mind: In Search of a Fundamental Theory, New York: Oxford University Press. 1996.
    3. Penrose R. The Emperor's New Mind. New York, NY: Penguin Books. 1989; ISBN 0-14-01-4534-6.
    4. Jedlicka P. Revisiting the Quantum Brain Hypothesis: Toward Quantum (Neuro)biology? Front Mol Neurosci. 2017 Nov 7; 10:366. doi: 10.3389/fnmol.2017.00366. PMID: 29163041; PMCID: PMC5681944.
    5. Lambert N, Chen YN, Cheng YC. Quantum biology. Nature Phys. 2013; 9:10–18. https://doi.org/10.1038/nphys2474.
    6. McFadden J, Al-Khalili J. The origins of quantum biologyProc. R. Soc. 2018; A.4742018067420180674 http://doi.org/10.1098/rspa.2018.0674
    7. Tegmark M. Importance of quantum decoherence in brain processes. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Apr;61(4 Pt B):4194-206. doi: 10.1103/physreve.61.4194. PMID: 11088215.
    8. Seife C. Neuroscience. Cold numbers unmake the quantum mind. Science. 2000 Feb 4;287(5454):791. doi: 10.1126/science.287.5454.791. PMID: 10691548.
    9. Penrose R, Hameroff S. Consciousness in the Universe: Neuroscience, Quantum Space-Time Geometry and Orch OR Theory, Journal of Cosmology. 2011; 14.
    10. Marais A, Adams B, Ringsmuth AK, Ferretti M, Gruber JM, Hendrikx R, Schuld M, Smith SL, Sinayskiy I, Krüger TPJ, Petruccione F, van Grondelle R. The future of quantum biology. J R Soc Interface. 2018 Nov 14;15(148):20180640. doi: 10.1098/rsif.2018.0640. PMID: 30429265; PMCID: PMC6283985.
    11. Chalmers DJ, McQueen KJ. Consciousness and the Collapse of the Wave Function. Consciousness and Quantum Mechanics. 2022; 11.
    12. Kremnizer K, Ranchin A. Integrated Information-Induced Quantum Collapse, Foundations of Physics. 2015; 45:8; 889-899.
    13. Neumann VJ. Mathematical Foundations of Quantum Mechanics/Mathematische Grundlagen der Quantenmechanik. Springer. 1932.
    14. Tononi G. An information integration theory of consciousness. BMC Neurosci. 2004 Nov 2;5:42. doi: 10.1186/1471-2202-5-42. PMID: 15522121; PMCID: PMC543470.
    15. Oizumi M, Albantakis L, Tononi G. From the phenomenology to the mechanisms of consciousness: Integrated Information Theory 3.0. PLoS Comput Biol. 2014 May 8;10(5):e1003588. doi: 10.1371/journal.pcbi.1003588. PMID: 24811198; PMCID: PMC4014402.
    16. Albantakis L, Barbosa L, Findlay G, Grasso M, Haun AM, Marshall W, Mayner WGP, Zaeemzadeh A, Boly M, Juel BE, Sasai S, Fujii K, David I, Hendren J, Lang JP, Tononi G. Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms. PLoS Comput Biol. 2023 Oct 17;19(10):e1011465. doi: 10.1371/journal.pcbi.1011465. PMID: 37847724; PMCID: PMC10581496.
    17. Kleiner J, Tull S. The Mathematical Structure of Integrated Information Theory, Front. Appl. Math. Stat. 2020; 6:2020 https://doi.org/10.3389/fams.2020.602973.
    18. Zanardi P, Tomka M, Venuti LC. Quantum Integrated Information Theory. 2018. arXiv preprint arXiv:1806.01421, Comparison with Standard Presentation of IIT 3.0.
    19. Lau H. Open letter to NIH on Neuroethics Roadmap (BRAIN initiative) 2019. In Consciousness We Trust. 2020. https://inconsciousnesswetrust.blogspot.com/2020/05/open-letter-to-nih-on-neuroethics.html.
    20. Merker B, Williford K, Rudrauf D. The integrated information theory of consciousness: A case of mistaken identity. Behav Brain Sci. 2021 May 19; 45:e41. doi: 10.1017/S0140525X21000881. PMID: 34006338.
    21. Grindrod P, Lee TE. On strongly connected networks with excitable-refractory dynamics and delayed coupling. R Soc Open Sci. 2017 Apr 5;4(4):160912. doi: 10.1098/rsos.160912. PMID: 28484610; PMCID: PMC5414247.
    22. Grindrod P, Lester C. Cortex-like complex systems: what occurs within?, Frontiers in Applied Mathematics and Statistics. 2021; 7:51. https://www.frontiersin.org/article/10.3389/fams.2021.627236.
    23. Grindrod P, Brennan M. Cognition and Consciousness Entwined. Brain Sci. 2023 May 28;13(6):872. doi: 10.3390/brainsci13060872. PMID: 37371352; PMCID: PMC10296586.
    24. Kahneman D. Thinking, Fast and Slow, Farrar, Straus and Giroux, New York. 2011.
    25. Furber SB, Galluppi F, Temple S, Plana LA. The SpiNNaker Project, Proceedings of the IEEE. 2014; 102 (5): 652–665.
    26. Grindrod P. On human consciousness: A mathematical perspective. Netw Neurosci. 2018 Mar 1;2(1):23-40. doi: 10.1162/NETN_a_00030. PMID: 30793070; PMCID: PMC6353040.
    27. Eliasmith C, Trujillo O. The use and abuse of large-scale brain models. Curr Opin Neurobiol. 2014 Apr; 25:1-6. doi: 10.1016/j.conb.2013.09.009. Epub 2013 Oct 11. PMID: 24709593.
    28. Chen S, He Z, Han X, He X, Li R, Zhu H, Zhao D, Dai C, Zhang Y, Lu Z, Chi X, Niu B. How Big Data and High-performance Computing Drive Brain Science. Genomics Proteomics Bioinformatics. 2019 Aug;17(4):381-392. doi: 10.1016/j.gpb.2019.09.003. Epub 2019 Dec 2. PMID: 31805369; PMCID: PMC6943776.
    29. DeBole MV, Appuswamy R, Carlson PJ, Cassidy AS, Datta P, Esser SK, TrueNorth: Accelerating from Zero to 64 Million Neurons in 10 Years. Computer. 2019; 52(5):20–9.
    30. Temple S, Furber S. Neural Systems Engineering. J R Soc Interf. 2007; 4(13):193–206. doi:10.1098/rsif.2006.0177 CrossRef Full Text | Google Scholar
    31. Moss S. SpiNNaker: Brain Simulation Project Hits One Million Cores on a Single Machine Modeling the Brain Just Got a Bit Easier. Data Center Dynamics. 2018. https://www.datacenterdynamics.com/en/news/spinnaker-brain-simulation-project-hits-one-million-cores-single-machine/(October 16, 2018).
    32. Mullin E. How big science failed to unlock the mysteries of the human brain, MIT Tech Review. 2021. https://www.technologyreview.com/2021/08/25/1032133/big-science-human-brain-failure/.
    33. The Human Brain Project. 2020. https://en.wikipedia.org/wiki/Human_Brain_Project (extracted May 2020).
    34. Grindrod P, Brennan M. Generalised Kuramoto models with time-delayed phase-resetting for -dimensional clocks, Brain Multiphysics. 2023; 4. https://doi.org/10.1016/j.brain.2023.100070.
    35. Wigner EP. Remarks on the mind-body question. Philosophical reflections and syntheses. 1995; 247-260.
    36. Dennett DC. Consciousness Explained, Little, Brown and Co. 1991.
    37. Nani A, Manuello J, Mancuso L, Liloia D, Costa T, Cauda F. The Neural Correlates of Consciousness and Attention: Two Sister Processes of the Brain. Front Neurosci. 2019 Oct 31; 13:1169. doi: 10.3389/fnins.2019.01169. PMID: 31749675; PMCID: PMC6842945.

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