Neurology at IgMin Research | Medicine Group

Background: Levetiracetam is an anti-epileptic drug that works by modulation of synaptic neurotransmitter release through binding to the synaptic vesicle protein 2A. Levetiracetam is generally well tolerated. Common side effects of levetiracetam include lethargy, drowsiness, headaches, and mood changes. Rhabdomyolysis and an increase in Creatine Kinase (CK) levels are one of the rarely reported effects of levetiracetam.Case presentation: We present a case of a 20-year-old patient with previously known epilepsy (non-compliant with medicine) who ...presented with a seizure. The patient was given 1 gram of levetiracetam in the emergency department and was kept at a maintenance dose of 500 mg twice a day. The workup revealed acute kidney injury and raised levels of creatinine kinase that peaked at 19,757 IU/L 72 hours after levetiracetam was started. Levetiracetam was later switched to lamotrigine and aggressive intravenous hydration was done. Gradual improvement of CK level was noted accompanied by improvement in renal function.Conclusion: Only a few cases of levetiracetam-induced rhabdomyolysis have been reported worldwide. Our case report highlights the importance of monitoring creatinine and CK levels while treating patients with levetiracetam as rhabdomyolysis can be asymptomatic with a rise in CK levels only.Read more

Post-stroke aphasia and hand movement dysfunction are common and disabling conditions. Observations indicate that most patients with post-stroke aphasia also suffer from hand movement dysfunction. Research in human evolution, behavior, and neuroscience has revealed a strong connection between language function and hand-motor function, with the latter playing a critical role in language use. Consequently, there is an urgent need for the development of new, comprehensive, and efficient rehabilitation methods for post-stroke aphasia that is accomp...anied by hand dysfunction. One promising approach involves investigating the shared neural networks between language and hand function as a foundation for novel treatment methods. This article aims to review the current state of clinical research on comprehensive treatments for stroke-induced aphasia and hand dysfunction, as well as to explore their underlying neural mechanisms. The results of this study may provide a valuable reference for the advancement of treatment technologies that effectively address both dysfunctions and enhance clinical outcomes.Read more

This study examined upper limb kinematics under simulated visually impaired conditions. By investigating how upper limb movements adapt in these circumstances, we aimed to gain insights that may prove valuable for both healthy populations and those with clinical conditions. Data, including 3D marker-based motion capture and accelerometer readings, were collected from seven healthy volunteers walking on a treadmill at 1.5 m/s under two conditions: without glasses (NG) and with stroboscopic glasses (G). Each walking condition lasted 2 minutes, an...d two 10-second recordings were analyzed from the midpoint of each session. Contrary to our hypothesis, simulated visual impairment with stroboscopic eyewear at 6Hz did not statistically affect upper limb kinematics, specifically in terms of wrist acceleration and hand distance in the frontal plane. Future research should explore varied visual impairment conditions, extend task durations, and investigate the relationship between subjective gait difficulties and biomechanical data.Read more