Help ?

IGMIN: We're glad you're here. Please click "create a new query" if you are a new visitor to our website and need further information from us.

If you are already a member of our network and need to keep track of any developments regarding a question you have already submitted, click "take me to my Query."

Discover the nexus of Science, Technology, Engineering, and Medicine in our Multidisciplinary Open Access Journal – a platform for breakthroughs and collaborative expertise, driving knowledge and innovation. | Important Update! Building on our inaugural year's success, adjustments to article processing charges will take effect in October. More details coming soon!

Abstract at IgMin Research

Our mission is to foster interdisciplinary dialogue and accelerate the advancement of knowledge across a wide spectrum of scientific domains.

Medicine Group Mini Review Article ID: igmin141

Association and New Therapy Perspectives in Post-Stroke Aphasia with Hand Motor Dysfunction

Neurology Medical ResearchRehabilitation Medicine Affiliation


    Department of Rehabilitation Medicine, Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical University, Zhangzhou, 363000, Fujian Province, China


Post-stroke aphasia and hand movement dysfunction are common and disabling conditions. Observations indicate that most patients with post-stroke aphasia also suffer from hand movement dysfunction. Research in human evolution, behavior, and neuroscience has revealed a strong connection between language function and hand-motor function, with the latter playing a critical role in language use. Consequently, there is an urgent need for the development of new, comprehensive, and efficient rehabilitation methods for post-stroke aphasia that is accompanied by hand dysfunction. One promising approach involves investigating the shared neural networks between language and hand function as a foundation for novel treatment methods. This article aims to review the current state of clinical research on comprehensive treatments for stroke-induced aphasia and hand dysfunction, as well as to explore their underlying neural mechanisms. The results of this study may provide a valuable reference for the advancement of treatment technologies that effectively address both dysfunctions and enhance clinical outcomes.



    1. Grönberg A, Henriksson I, Stenman M. Incidence of Aphasia in Ischemic Stroke. Neuroepidemiology. 2022; 56(3): 174-182.
    2. Lawrence ES, Coshall C, Dundas R. Estimates of the prevalence of acute stroke impairments and disability in a multiethnic population. Stroke. 2001; 32(6):1279-1284.
    3. Zhou X, Qu L, Zhang W. Analysis of Proteomic Characteristics of Peripheral Blood in Preeclampsia and Study of Changes in Fetal Arterial Doppler Parameters Based on Magnetic Nanoparticles. Computational and mathematical methods in medicine. 2021; 2021: 7145487.
    4. Edelkraut L, López-Barroso D, Torres-Prioris MJ. Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia. World journal of psychiatry. 2022; 12(3): 450-469.
    5. Anderlini D, Wallis G, Marinovic W. Language as a Predictor of Motor Recovery: The Case for a More Global Approach to Stroke Rehabilitation. Neurorehabilitation and neural repair. 2019; 33(3): 167-178.
    6. Wortman-Jutt S, Edwards D. Poststroke Aphasia Rehabilitation: Why All Talk and No Action? Neurorehabilitation and neural repair. 2019.
    7. Xu S, Yan Z, Pan Y. Associations between Upper Extremity Motor Function and Aphasia after Stroke: A Multicenter Cross-Sectional Study. Behavioural Neurology. 2021; 2021: 1-10.
    8. Thibault S, Py R, Gervasi AM. Tool use and language share syntactic processes and neural patterns in the basal ganglia. Science. 2021; 374(6569).
    9. Gough PM, Riggio L, Chersi F. Nouns referring to tools and natural objects differentially modulate the motor system. Neuropsychologia. 2012; 50(1): 19-25.
    10. Cobble M. Language impairment in motor neurone disease. Journal of the neurological sciences. 1998;160 Suppl 1: S47-S52.
    11. Bak TH, Hodges JR. The effects of motor neurone disease on language: further evidence. Brain and language. 2004; 89(2): 354-361.
    12. Wan CY, Demaine K, Zipse L. From music making to speaking: engaging the mirror neuron system in autism. Brain research bulletin. 2010; 82(3-4): 161-168.
    13. Miyahara M, Kitada R, Sasaki AT. From gestures to words: spontaneous verbal labeling of complex sequential hand movements reduces fMRI activation of the imitation-related regions. Neuroscience research. 2013; 75(3): 228-238.
    14. Rizzolatti G, Fadiga L, Matelli M. Localization of grasp representations in humans by PET: 1. Observation versus execution. Experimental brain research. 1996;111(2): 246-252.
    15. Rizzolatti G, Luppino G, Matelli M. The organization of the cortical motor system: new concepts. Electroencephalography and clinical neurophysiology. 1998; 106(4): 283-296.
    16. Rizzolatti G, Arbib MA. Language within our grasp. Trends in neurosciences, 1998; 21(5): 188-194.
    17. Jo S, Kim H, Song C. A Novel Approach to Increase Attention during Mirror Therapy among Stroke Patients: A Video-Based Behavioral Analysis. Brain sciences. 2022;12(3).
    18. Dai C, Peng Z, Wang L. Total sleep deprivation reduces the table tennis anticipation performance of young men: A functional magnetic resonance imaging study. iScience. 2023; 26(10): 107973.
    19. Von Heiseler TN. Syntax of Testimony: Indexical Objects, Syntax, and Language or How to Tell a Story Without Words. Frontiers in psychology. 2019;10: 477.
    20. Hesling I, Labache L, Joliot M. Large-scale plurimodal networks common to listening to, producing and reading word lists: an fMRI study combining task-induced activation and intrinsic connectivity in 144 right-handers. Brain structure & function. 2019; 224(9): 3075-3094.
    21. Ochfeld E, Newhart M, Molitoris J. Ischemia in broca area is associated with broca aphasia more reliably in acute than in chronic stroke. Stroke. 2010; 41(2): 325-330.
    22. Kiran S. What is the nature of poststroke language recovery and reorganization? ISRN neurology. 2012; 2012: 786872.
    23. Chen W, Ye Q, Zhang S. Aphasia rehabilitation based on mirror neuron theory: a randomized-block-design. Neural regeneration research. 2019;14(6): 1004-1012.
    24. Chen W, Ye Q, Ji X. Mirror neuron system based therapy for aphasia rehabilitation. Frontiers in psychology. 2015; 6: 1665.
    25. Gili T, Fiori V, De Pasquale G. Right sensory-motor functional networks subserve action observation therapy in aphasia. Brain imaging and behavior. 2017;11(5): 1397-1411.
    26. Marangolo P, Bonifazi S, Tomaiuolo F. Improving language without words: first evidence from aphasia. Neuropsychologia. 2010; 48(13): 3824-3833.
    27. Beilock SL, Lyons IM, Mattarella-Micke A. Sports experience changes the neural processing of action language. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(36): 13269-13273.
    28. Turkeltaub PE. Brain Stimulation and the Role of the Right Hemisphere in Aphasia Recovery. Current neurology and neuroscience reports. 2015; 15(11): 72.
    29. Barwood CHS, Murdoch BE, Riek S. Long term language recovery subsequent to low frequency rTMS in chronic non-fluent aphasia. NeuroRehabilitation. 2013; 32(4): 915-928.
    30. Thiel A, Hartmann A, Rubi-Fessen I. Effects of noninvasive brain stimulation on language networks and recovery in early poststroke aphasia. Stroke. 2013; 44(8): 2240-2246.
    31. Naeser MA, Martin PI, Nicholas M. Improved picture naming in chronic aphasia after TMS to part of right Broca's area: an open-protocol study. Brain and language. 2005; 93(1): 95-105.
    32. Hartwigsen G, Saur D, Price CJ. Perturbation of the left inferior frontal gyrus triggers adaptive plasticity in the right homologous area during speech production. Proceedings of the National Academy of Sciences of the United States of America. 2013;110(41): 16402-16407.
    33. Pulvermüller F, Schönle P W. Behavioral and neuronal changes during treatment of mixed transcortical aphasia: a case study. Cognition. 1993; 48(2): 139-161.
    34. Saur D, Hartwigsen G. Neurobiology of language recovery after stroke: lessons from neuroimaging studies. Archives of physical medicine and rehabilitation. 2012; 93(1 Suppl): S15-S25.
    35. Vargha-Khadem F, Carr LJ, Isaacs E. Onset of speech after left hemispherectomy in a nine-year-old boy. Brain: a journal of neurology. 1997;120 (Pt 1): 159-182.
    36. Al-Janabi S, Nickels LA, Sowman PF. Augmenting melodic intonation therapy with non-invasive brain stimulation to treat impaired left-hemisphere function: two case studies. Frontiers in psychology. 2014; 5: 37.
    37. Heikkinen PH, Pulvermüller F, Mäkelä JP. Combining rTMS with Intensive Language-Action Therapy in Chronic Aphasia: A Randomized Controlled Trial. 2018; 12:1036.
    38. Xu S, Yang Q, Chen M. Capturing Neuroplastic Changes after iTBS in Patients with Post-Stroke Aphasia: A. Brain sciences. 2021;11(11).
    39. Baker JM, Rorden C, Fridriksson J. Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke. 2010; 41(6): 1229-1236.
    40. Fiori V, Coccia M, Marinelli CV. Transcranial direct current stimulation improves word retrieval in healthy and nonfluent aphasic subjects. Journal of cognitive neuroscience. 2011; 23(9): 2309-2323.
    41. Meinzer M, Darkow R, Lindenberg R. Electrical stimulation of the motor cortex enhances treatment outcome in post-stroke aphasia. Brain: a journal of neurology. 2016;139(Pt 4): 1152-1163.
    42. Meinzer M, Lindenberg R, Sieg MM. Transcranial direct current stimulation of the primary motor cortex improves word-retrieval in older adults. Frontiers in aging neuroscience. 2014; 6: 253.

Similar Articles

Diagnostic Challenges in Pancreatic Tumors
Ionuţ Simion Coman, Elena Violeta Coman, Costin George Florea, Teodora Elena Tudose, Cosmin Burleanu, Anwar Erchid and Valentin Titus Grigorean
DNA Genetics and UHPLC-Q-TOF-MS Analysis of Phytochemicals for Asparagus racemosus Roots
Nguyen Thi Huong, Do Ngoc Thuy, Phung van Trung, Le Ngoc Hung and Mai van Nam