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Medicine Group Case Report Article ID: igmin154

A Rare Case of Recurrent Vulvovaginal Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP)

Pathology Obstetrics OncologyGynecology
Sakshi Zawar * 1 ,
Priyanka Chaudhari 2 ,
Viraj Borgaonkar 3 and
Utpal Gaikwad 4
Affiliation

Affiliation

    Department of Gynaecology, Oncology, Krupamayi Hospital, Aurangabad, Maharashtra, India

    Department of Gynaecology, Oncology, Krupamayi Hospital, Aurangabad, Maharashtra, India

    Department of Histopathology, Krupamayi Hospital, Aurangabad, Maharashtra, India

    Department of Surgical Oncology, Krupamayi Hospital, Aurangabad, Maharashtra, India

    Department of Radiation Oncology, Krupamayi Hospital, Aurangabad, Maharashtra, India

DOI10.61927/igmin154 Fulltext HTML Fulltext PDF Cite this article
DOI10.61927/igmin154 Fulltext HTML Fulltext PDF Cite this article

Abstract

Smooth muscle tumours are the most common mesenchymal tumors of the vulva and vagina, yet their infrequency is demonstrated by the prevalence of published reports as individual cases or small case series.
This article reports a case of a 42-year-old woman who presented with apparently recurrent vulvovaginal leiomyoma and a past history of surgical excisions. Histopathology revealed Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP).

Figures

Anterior vaginal wall tumor. Figure 1: Anterior vaginal wall tumor....
Intraoperative dissection of vaginal tumor. Figure 2: Intraoperative dissection of vaginal tumor....
Intraoperative dissection of vulval tumor. Figure 3: Intraoperative dissection of vulval tumor....
Vulval tumor with smooth external surface. Figure 4: Vulval tumor with smooth external surface....
Sections show sheets and fascicles of spindle-shaped cells with focal mild nuclear Atypia with fibro-collagenous stroma, no necrosis, and mitoses < 5/10 HPF. (Magnification 400x). Figure 5: Sections show sheets and fascicles of spindle-shap...
Sections show sheets and fascicles of spindle-shaped cells with focal mild nuclear Atypia with fibro-collagenous stroma, no necrosis, and mitoses < 5/10 HPF. (Magnification 400x). Figure 6: Sections show sheets and fascicles of spindle-shap...

References

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    2. Chapel DB, Nucci MR, Quade BJ, Parra-Herran C. Epithelioid Leiomyosarcoma of the Uterus: Modern Outcome-based Appraisal of Diagnostic Criteria in a Large Institutional Series. Am J Surg Pathol. 2022 Apr 1;46(4):464-475. doi: 10.1097/PAS.0000000000001795. PMID: 34419987.
    3. IARC Publications Website - WHO Classification of Tumours [Internet]. [cited 2024 Feb 18]. https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours
    4. Mills AM, Longacre TA. Smooth Muscle Tumors of the Female Genital Tract. Surg Pathol Clin. 2009 Dec;2(4):625-77. doi: 10.1016/j.path.2009.08.019. Epub 2009 Nov 29. PMID: 26838774.
    5. Gowri R, Soundararaghavan S, Oumachigui A, Sistla SC, Iyengar KR. Leiomyoma of the vagina: an unusual presentation. J Obstet Gynaecol Res. 2003 Dec;29(6):395-8. doi: 10.1111/j.1341-8076.2003.00135.x. PMID: 14641688.
    6. Newman PL, Fletcher CD. Smooth muscle tumours of the external genitalia: clinicopathological analysis of a series. Histopathology. 1991 Jun;18(6):523-9. doi: 10.1111/j.1365-2559.1991.tb01479.x. Erratum in: Histopathology 1991 Aug;19(2):198. PMID: 1879812.
    7. Langley FA. Malignant tumours of the uterine mesenchyme. Clin Obstet Gynaecol. 1976 Aug;3(2):425-57. PMID: 188590.
    8. Smooth muscle tumors of uncertain malignant potential [Internet]. [cited 2024 Feb 18]. https://www.pathologyoutlines.com/topic/uterusSTUMP.html
    9. Viau M, Plante M, Renaud MC, Grondin K, Morin C. Proposed novel nomenclature of vulvar smooth muscle tumors; a case of Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP) of the vulva. Gynecol Oncol Rep. 2017 May; 20:1–3.
    10. Swanson AA, Howitt BE, Schoolmeester JK. Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas. Hum Pathol. 2020 Sep;103:83-94. doi: 10.1016/j.humpath.2020.06.008. Epub 2020 Jul 17. PMID: 32687944.
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    12. Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2009 Jul;33(7):992-1005. doi: 10.1097/PAS.0b013e3181a02d1c. PMID: 19417585.
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