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Focusing on Science, Technology, Engineering and Medicine (STEM) disciplines | ISSN: 2995-8067  G o o g l e  Scholar

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IgMin Research | a Multidisciplinary Open Access Journal is a prestigious multidisciplinary journal committed to the advancement of research and knowledge in the expansive domains of science, technology, engineering and Medical Sciences (STEM).

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Genomics is a cutting-edge field within biology that focuses on the study of genomes – the complete sets of genes and genetic material present in an organism. By analyzing and comparing genomes, genomics reveals insights into the genetic blueprint that governs the development, function, and evolution of all living beings. This field has revolutionized our understanding of hereditary traits, diseases, and the intricacies of life's diversity.

Genomic research involves technologies like DNA sequencing, allowing scientists to map entire genomes and identify variations within them. This information is vital for deciphering the genetic basis of diseases, designing personalized medicine, and enhancing our understanding of evolution. Genomics is at the forefront of scientific progress, unlocking the secrets embedded within our DNA.

  • Whole genome sequencing
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Mini Review Article ID: igmin238
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Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

Revisit TBCK-A Pseudo Kinase or a True Kinase
by Jin Wu and Jianjun Zhu

Since the initial identification of TBCK (formerly MGC16169) in 2010, significant advances have been made in understanding the role of TBCK mutations in neurodevelopmental disorders such as TBCK encephalopathy. However, the precise function and detailed mechanisms of TBCK remain largely unexplored. Previous studies, including our own, suggest that aberrant expression or mutations in TBCK can impact cell growth, division, and cytoskeleton assembly, contributing to both cancer and neurogenetic diseases. Despite this, the specific domains within T...BCK responsible for these functions are still unclear. Notably, mutations in the TBC domain have been implicated in disrupting mTOR pathways, linking TBCK dysfunction to neurogenetic disorders and cancers. Given TBCK’s diverse roles, we have focused on its putative kinase domain. Through comprehensive analysis using tools such as Kinase Tree, AlphaFold2, Clustal Omega, and SMART, we discovered that TBCK lacks the key “D” residue in the conserved “HRD” and “DFG” motifs typical of protein kinases like PKA and SRC, suggesting TBCK functions as a pseudokinase. Intriguingly, gene ontology analysis from recent RNA-seq data indicates TBCK’s involvement in regulating protein phosphorylation. This suggests that TBCK may influence protein phosphorylation either directly through its potential kinase domain or indirectly via interactions with other proteins. To uncover the full spectrum of TBCK’s roles in neurogenetic disorders and cancer, urgent high-throughput analyses are necessary to identify its interacting partners.

Molecular Biology GenomicsCell Science