stem3.jpg
Science

Molecular Biology at IgMin Research | Science Group

Our mission is to foster interdisciplinary dialogue and accelerate the advancement of knowledge across a wide spectrum of scientific domains.

About

Molecular medicine is a cutting-edge discipline that merges insights from molecular biology, genetics, and medicine to understand the underlying mechanisms of diseases at the molecular level. This field seeks to unravel the intricate molecular pathways and cellular processes that contribute to health and disease. By dissecting the molecular basis of disorders, researchers can develop targeted therapies, precision medicine approaches, and innovative diagnostic tools.

The study of molecular medicine involves investigating genes, proteins, signaling pathways, and other molecular components that drive biological functions. This knowledge is integral for identifying biomarkers, understanding disease progression, and devising strategies to intervene and restore cellular balance. Molecular medicine has revolutionized the way we approach diagnosis, treatment, and prevention of a wide range of medical conditions.

  • Genetic Disorders and Therapies
  • Molecular Diagnostics
  • Molecular Imaging
  • Precision Medicine
  • Biomarker Discovery
  • Molecular Pathology
  • Pharmacogenomics
  • Personalized Therapeutics
  • Molecular Oncology
  • Molecular Immunology
  • Molecular Neurobiology
  • Cellular Signaling
  • Molecular Targets for Drug Development
  • Molecular Epidemiology
  • Molecular Genetics
  • Proteomics
  • Transcriptomics
  • Metabolomics
  • Molecular Mechanisms of Aging
  • Molecular Cardiology
  • Molecular Hematology
  • Molecular Endocrinology
  • Molecular Infectious Diseases
  • Molecular Theranostics
  • Molecular Health Interventions

Science Group (5)

Research Article Article ID: igmin175
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

LC-MS and HPLC-UV for Detecting Uremic Toxins: Two Validated Methods with Simultaneous Sensitivity and Specificity Evaluation
by Cristina Filosa

Uremic toxins (UTs) are compounds derived from the metabolism of dietary molecules such as tryptophan (Indossyl Sulphate, IS) and phenil-alanine (P-Cresyl Sulphate, PCS), that are normally eliminated by the kidneys of healthy patients. The accumulation of such toxins is an indicator of kidney disease at different degrees of severity, and the toxins can be found as free or protein bound in human biological samples. The toxicity of such compounds causes the loss of several biological functions, and the subjects suffering from such complications w...ill need, more often than not, hemodialysis to properly excrete these toxins. Despite this not being a resolutive, but rather a symptom managing clinical approach, this is the most common course of treatment. Two analytical methods are proposed to quantify both the protein-bound and free forms of IS and PCS (HPLC-UV for the former; LC-MS/MS with ESI negative ionization for the latter), with lower variability and higher robustness than what is currently proposed, allowing for a precise simultaneous determination of the aforementioned UTs.

Molecular Biology
Mini Review Article ID: igmin143
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

The Model for Clinical, Laboratory, and Genetic Prediction of Recurrent Ischemic Stroke against the Background of Laboratory Aspirin Resistance using Machine Learning
by Anastasia V Anisimova, Sergey S Galkin, Anastasia S Gunchenko, Tatyana V Nasedkina and Igor V Vorobiev

The aim of the study was to determine the incidence of laboratory aspirin resistance; and to study the associations of genetic markers and clinical and laboratory parameters (including parameters of the platelet hemostasis) in patients with non-cardioembolic ischemic stroke using machine learning methods to assess the prognosis of recurrent ischemic strokes. Clinical and laboratory data (including induced platelet aggregation) were analyzed from 296 patients with ischemic stroke who were treated in the stroke center of City Clinical Hospital No.... 1 named after. N.I. Pirogov. The frequencies of polymorphic variants of the ITGB3, GPIba, TBXA2R, ITGA2, PLA2G7, HMOX1, PTGS1, PTGS2, ADRA2A, ABCB1, PEAR1 genes and intergenic region 9p21.3) in patients with non-cardioembolic ischemic stroke, which were identified using hydrogel biochip technology, were determined. Using the developed machine learning model, additional clinical and genetic factors influencing the development of laboratory aspirin resistance and recurrent ischemic stroke were studied. In the future, the identified factors can be used for differentiated prevention of recurrent ischemic strokes.

Molecular Biology
Mini Review Article ID: igmin142
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

Enforcement and Enlargement of the Saccharomyces cerevisiae Endoplasmic Reticulum through Artificial Evocation of the Unfolded Protein Response
by Masaki Monguchi and Yukio Kimata

Upon dysfunction of the Endoplasmic Reticulum (ER), eukaryotic cells provoke a gene expression program, namely, the Unfolded Protein Response (UPR), leading to an increase in the size and function of the ER. In the yeast Saccharomyces cerevisiae, the UPR is modulated by the Hac1i protein, which is a transcription factor produced by ER stress. When the UPR is artificially triggered under non-stress conditions by artificial expression of the Hac1i protein, S. cerevisiae cells carry an enforced and enlarged ER, which allows us to obtain commercial...ly valuable materials such as secretory proteins and functional lipids abundantly.

Molecular Biology
Research Article Article ID: igmin133
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

Analytical Expressions of the Markov Chain of K-Ras4B Protein within the Catalytic Environment and a New Markov-State Model
by Orchidea Maria Lecian

The finite Markov chain to which there correspond the qualities of the conformational dynamics of the K-Ras4B proteins in the catalytic reaction is written. The corresponding Markov-Sates models are studied. The properties of the K-Ras4B processes Markov chain allow one to define a new two-state MSM for the analytical description of the final-state transition. The time evolution of the eigenvalue corresponding to the final-state transition in the Galerkin description is written. The tools for the analytical calculations of the relative error ...are therefore prepared. New analytical formulations of the time evolution of the eigenvalue corresponding to the final-state transition are newly written from the experimental data and form the properties of the lag time in shaping the discretization error. The features of the discretization error are newly studied. A comparison with the experimental data is proposed.

Computational Biology Molecular BiologyBiophysics
Research Article Article ID: igmin117
Cite

Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.

Homologous Series of Chemical Compounds in Three-component Systems (Aa+ – Bb+ – Cc–) and (Zn2+ - Ge4+ - P3-) in Generalized Form
by Undalov Yu K

For the first time, a method for calculating formulas of homologous series of chemical compounds of the systems (Aa+ – Bb+ – Cc–) and {Zn2+ – Ge4+ – P3–} in a generalized form is presented. The calculation is confirmed by the literature experimentally obtained compounds: thirteen compounds of the system (Na+ – Ti4+ – O2–), seven – systems (Li+ – Ti4+ – O2–), five – systems (K+ – V5a+ –  – O2–), eight – systems (Ba2+ – Cu2...+ – O2*). Homological series in (Aa+ – Bb+ – Cc–) have the following generalized form: A{t – k·r + nr – r)bcBracC{t – k·r + nr)ab and AtbcB{r – k·t + nt – t}acC (r – k·t + nt)ab.In (Zn2+ – Ge4+ – P3–) systems for the m-group the formulas of homologous series, that develops towards Ge3P4, have the following generalized form: Zn6tGe(6r – 6kt + 6n – 6t)P(8r – 8kt + 8n)  and for αm-homologous series – Zn6Ge3nP4(n + 1). A method for calculating formulas of homologous series of chemical compounds in a generalized form can be used for any system of chemical elements.

Inorganic Chemistry Molecular BiologyComputational Biology