Biochemistry at IgMin Research | Science Group

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Biochemistry is a captivating discipline that unravels the intricate molecular mechanisms underlying life's fundamental processes. It investigates the chemical interactions within biological systems, exploring how molecules like proteins, nucleic acids, lipids, and carbohydrates work together to drive cellular functions. Biochemistry serves as a bridge between biology and chemistry, shedding light on the molecular basis of health, diseases, and living organisms' behavior.

Biochemists delve into a wide spectrum of topics, from enzyme kinetics to the structure of DNA. This field has revolutionized our understanding of metabolism, genetics, and the mechanisms that govern cellular communication. Biochemistry's insights have led to breakthroughs in medicine, biotechnology, and drug discovery, making it an essential cornerstone of modern scientific exploration.

  • Enzyme kinetics
  • Metabolic pathways
  • Protein structure and function
  • Nucleic acid chemistry
  • Lipid metabolism
  • Carbohydrate chemistry
  • Biochemical signaling
  • Hormones and receptors
  • Bioenergetics
  • Enzyme regulation
  • DNA replication and repair
  • RNA processing
  • Protein synthesis
  • Molecular genetics
  • Membrane biochemistry
  • Signal transduction
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  • Biochemical spectroscopy
  • Structural biology
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Science Group (1)

Short Communication Article ID: igmin177

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Isolation and Characterization of Active Alkaloid Compounds from Cinnamomum Verum Cortexes and Proof of their Medicinal Efficacy against Pathogenic Fungus Alternaria Alternate Causing Upper Respiratory Tract Inflammatory Disease
by Sanaa Qasem Badr

Six alkaloid compounds were isolated (the discovery of a natural drug, which is a combination of the six alkaloid compounds). Alkaloids viz., 1,3,5-Triazine-2-carboxylic acid, 4-amino-6-methyl; 1,2,4-Triazino[5,6-E][1,2,4]-triazine-3,6-dione, hexahydro; 2-(4,5-Dihydro-3-methyl-5-oxo-1-phenyl-4-pyrazole)-5-nitrobenzoic ...acid; 4-metyl-3,4-dihydro-[1,2,3] trizolo [4,5-d] pyrimidine-5,7-dione; Propanoic acid-3-(perhydro-2,5-dioxo-imidazol [4,5-d] imidazole-1-yl) and 1,2,3-Triazolo[4,5-f] benzotriazole- 4,8(4H,8H)-dione, were isolated from Cinnamomum verum cortexes by using ethanolic acetic acid, sulphuric acid, and ammonia solvents, and they were characterized by using preliminary qualitative tests, gas chromatography-mass spectrumGC-MASS.The medicinal efficacy was studied for these six alkaloidic compounds theoretically by using the Autodock program and the results showed the presence of high efficacy of the compounds. Then the medicinal efficacy was measured biologically for the six compounds mixture in vitro depending on the synergistic interaction principle by using various concentrations (5, 10, 15, 20, and 25 mg/ml) by using of agar diffusion technique. The results showed that the six alkaloidic compounds’ mixture is biologically active against Alternaria alternate fungus, where the inhibition zone diameters were recorded equal to 27, 33, 41, 45, and 49 mm respectively towards the pathogenic fungus. Also, cytotoxicity tests for the different concentrations of six active alkaloid compounds mixture proved there is no toxic effect belonging to them towards red blood cells, and no hemolysis effect appeared in blood cells. Therefore, six alkaloid compounds isolated from Cinnamomum verum cortexes can be used as active drugs for the treatment of various diseases especially those caused by pathogenic fungi represented by Alternaria alternate, without any side effects.

Biochemistry MicrobiologyEthnomedicine