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Microbiology at IgMin Research | Science Group

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Microbiology is the scientific exploration of microorganisms – tiny life forms that include bacteria, viruses, fungi, and protozoa. These microorganisms play pivotal roles in various ecosystems, industries, and human health. Microbiology delves into the study of their structure, functions, genetics, and interactions, uncovering the profound impact they have on our world.

Microbiologists investigate diverse topics, ranging from the role of beneficial bacteria in our gut to the mechanisms of infectious diseases. This field has paved the way for advances in medicine, biotechnology, agriculture, and environmental science, reshaping our understanding of life on Earth and influencing innovative solutions to global challenges.

 

  • Bacteriology
  • Virology
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  • Environmental microbiology
  • Microbial biotechnology
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  • Microbial evolution
  • Microbial pathogenesis
  • Microbial interactions
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  • Microbial enzymes
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  • Microbial bioremediation
  • Microbial resistance
  • Microbial genomics
  • Microbial diagnostics
  • Microbial physiology
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Short Communication Article ID: igmin177
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Isolation and Characterization of Active Alkaloid Compounds from Cinnamomum Verum Cortexes and Proof of their Medicinal Efficacy against Pathogenic Fungus Alternaria Alternate Causing Upper Respiratory Tract Inflammatory Disease
by Sanaa Qasem Badr

Six alkaloid compounds were isolated (the discovery of a natural drug, which is a combination of the six alkaloid compounds). Alkaloids viz., 1,3,5-Triazine-2-carboxylic acid, 4-amino-6-methyl; 1,2,4-Triazino[5,6-E][1,2,4]-triazine-3,6-dione, hexahydro; 2-(4,5-Dihydro-3-methyl-5-oxo-1-phenyl-4-pyrazole)-5-nitrobenzoic ...acid; 4-metyl-3,4-dihydro-[1,2,3] trizolo [4,5-d] pyrimidine-5,7-dione; Propanoic acid-3-(perhydro-2,5-dioxo-imidazol [4,5-d] imidazole-1-yl) and 1,2,3-Triazolo[4,5-f] benzotriazole- 4,8(4H,8H)-dione, were isolated from Cinnamomum verum cortexes by using ethanolic acetic acid, sulphuric acid, and ammonia solvents, and they were characterized by using preliminary qualitative tests, gas chromatography-mass spectrumGC-MASS.The medicinal efficacy was studied for these six alkaloidic compounds theoretically by using the Autodock program and the results showed the presence of high efficacy of the compounds. Then the medicinal efficacy was measured biologically for the six compounds mixture in vitro depending on the synergistic interaction principle by using various concentrations (5, 10, 15, 20, and 25 mg/ml) by using of agar diffusion technique. The results showed that the six alkaloidic compounds’ mixture is biologically active against Alternaria alternate fungus, where the inhibition zone diameters were recorded equal to 27, 33, 41, 45, and 49 mm respectively towards the pathogenic fungus. Also, cytotoxicity tests for the different concentrations of six active alkaloid compounds mixture proved there is no toxic effect belonging to them towards red blood cells, and no hemolysis effect appeared in blood cells. Therefore, six alkaloid compounds isolated from Cinnamomum verum cortexes can be used as active drugs for the treatment of various diseases especially those caused by pathogenic fungi represented by Alternaria alternate, without any side effects.

Biochemistry MicrobiologyEthnomedicine