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Welcome to IgMin Research – an Open Access journal uniting Biology, Medicine, and Engineering. We’re dedicated to advancing global knowledge and fostering collaboration across scientific fields.
At IgMin Research, we bridge the frontiers of Biology, Medicine, and Engineering to foster interdisciplinary innovation. Our expanded scope now embraces a wide spectrum of scientific disciplines, empowering global researchers to explore, contribute, and collaborate through open access.
Welcome to IgMin, a leading platform dedicated to enhancing knowledge dissemination and professional growth across multiple fields of science, technology, and the humanities. We believe in the power of open access, collaboration, and innovation. Our goal is to provide individuals and organizations with the tools they need to succeed in the global knowledge economy.
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Biography
Dr. Edgar Krötzsch is a distinguished researcher and the head of the Laboratory of Connective Tissue at the National Rehabilitation Institute “Luis Guillermo Ibarra Ibarra” in Mexico City. His laboratory specializes in understanding the molecular and cellular mechanisms underlying wound healing, with a particular focus on the role of extracellular matrix components such as fibrin in tissue repair processes.
Dr. Krötzsch's research has significantly contributed to the field of dermatology and pathology. Notably, his study titled “Fibrin Contributes to an Improvement of an in vitro Wound Repair Model using Fibroblast-populated Collagen Lattices” was published in the March 2024 issue of IgMin Research, a multidisciplinary open-access journal. This work demonstrated how fibrin supplementation in fibroblast-populated collagen lattices enhances wound closure, providing valuable insights into tissue regeneration mechanisms.
In addition to his role at the National Rehabilitation Institute, Dr. Krötzsch has collaborated with researchers from the National Autonomous University of Mexico, reflecting his commitment to interdisciplinary research and the advancement of medical science in Mexico.
His contributions to the field are also recognized on platforms like ResearchGate, where his profile highlights his extensive research endeavors and collaborations.
Dr. Krötzsch's work continues to influence the understanding of connective tissue biology and wound healing, underscoring the importance of extracellular matrix components in tissue repair and regeneration.
Research Interest
Dr. Edgar Krötzsch's research interests lie in the molecular and cellular mechanisms of wound healing, with a primary focus on the role of the extracellular matrix (ECM) in tissue repair. He specializes in understanding how ECM components, such as fibrin, contribute to wound regeneration and tissue restoration. His work aims to enhance in vitro wound repair models, particularly fibroblast-populated collagen lattices, to better mimic physiological healing processes. By investigating the interaction between fibroblasts and ECM proteins, Dr. Krötzsch seeks to improve therapeutic approaches for accelerating wound closure. His interdisciplinary research integrates dermatology, pathology, and tissue engineering, with a goal of developing more effective treatments for patients with chronic wounds or injuries. Dr. Krötzsch also collaborates with leading institutions like the National Autonomous University of Mexico, reflecting his dedication to advancing medical science in the field of connective tissue biology and regenerative medicine.
Open Access Policy refers to a set of principles and guidelines aimed at providing unrestricted access to scholarly research and literature. It promotes the free availability and unrestricted use of research outputs, enabling researchers, students, and the general public to access, read, download, and distribute scholarly articles without financial or legal barriers. In this response, I will provide you with an overview of the history and latest resolutions related to Open Access Policy.
byMario Chopin-Doroteo, Aldo Montes de Oca-Delgado, Rosa M Salgado and Edgar Krötzsch
Incisional acute wounds of the skin are characterized by a rapid biomechanical response by stromal cell contraction that joins the wound lips through the fibrin cloth. In this work, we have performed an in vitro model using Fibroblast-Populated Collagen Lattices (FPCLs) that partially mimic that physiological process. Injured FPCLs under relaxed or stressed conditions were evaluated over time, and cross-sections of the lattices were stained with picrosirius red. Wounds filled with fibrin in relaxed FPCLs were closed earlier than controls, the f...ibrillar pattern of the collagen lattice was different between the wound and the edges of the lattice. On the other hand, stressed FPCLs did not close wounds, even those filled with fibrin, because the tension generated from the lattice borders maintained high tension towards the wound. Controls or fibrin-treated stressed FPCLs, showed high tension in the wound matrix, characterized by the high packing of collagen observed like yellow-red birefringent fibers when stained by picrosirius red. Despite wounds that remain open, fibrin-treated FPCLs exhibited less wound area than controls. With this work, we have demonstrated that FPCL models can be used to study wound closure, mainly when they are improved with other elements of the wound environment that allow us to analyze the biological process.
0000-0002-0696-0147 
